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Early events in the recognition of danger signals after tissue injury
Author(s) -
Kaczorowski David J.,
Mollen Kevin P.,
Edmonds Rebecca,
Billiar Timothy R.
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0607374
Subject(s) - sepsis , inflammation , biology , context (archaeology) , endogeny , tlr4 , shock (circulatory) , immunology , inflammatory response , host response , septic shock , systemic inflammation , hmgb1 , bioinformatics , immune system , medicine , endocrinology , paleontology
The systemic inflammatory response observed in the setting of overwhelming infection bears striking similarities to that observed in the setting of severe traumatic injury from a clinical and physiologic standpoint. Recent observations have demonstrated that these disparate clinical entities share common mediators on a molecular level. TLRs, specifically TLR4, and the endogenous molecule high‐mobility group box 1 are among the mediators that are known to play a role in inflammation in the setting of sepsis. Evidence is accumulating that demonstrates that these mediators also play a role in the host response to tissue injury. Here, we highlight findings from the 7th World Conference on Trauma, Shock, Inflammation and Sepsis in Munich, Germany, in the context of this growing body of literature.