Premium
Detection of immune danger signals by NALP3
Author(s) -
Marti Fabio
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0607362
Subject(s) - nalp3 , innate immune system , inflammasome , biology , immune system , aim2 , inflammation , immunity , immunology , caspase , pathogen associated molecular pattern , microbiology and biotechnology , pattern recognition receptor , apoptosis , programmed cell death , biochemistry
The innate immune system in animals has been forged to detect microbes, coordinate symbiotic responses, and mount immune defenses against pathogens. Recently, innate immunity was shown to detect signals released by damaged cells or tissues such as uric acid or ATP. These danger signals were proposed to be important in promoting and regulating inflammation upon trauma or pathogen insults. The physiological relevance of these signals in the immune response and their mechanisms of action are still unclear. Recent findings suggest that some danger signals activate the NALP3 inflammasome, an innate immune complex that controls inflammatory caspases and IL‐1 activation.