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Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage
Author(s) -
Bächli Esther B.,
Schaer Dominik J.,
Walter Roland B.,
Fehr Jörg,
Schoedon Gabriele
Publication year - 2006
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0605309
Subject(s) - cd163 , biology , haematopoiesis , myeloid , scavenger receptor , myeloid leukemia , myelopoiesis , immunology , cancer research , leukemia , macrophage , microbiology and biotechnology , stem cell , endocrinology , cholesterol , genetics , lipoprotein , in vitro
The hemoglobin–haptoglobin (Hb–Hp) scavenger receptor CD163 is a monocyte/macrophage‐restricted surface antigen, whose expression is strongly up‐regulated by glucocorticoids. We have previously shown that CD163 is expressed by acute myeloid leukemia (AML) cells of monocytic lineage. Herein, we expand this finding by demonstrating constitutive and glucocorticoid‐enhanced CD163 expression on French‐American‐British M4/M5 AML cells, and leukemic blasts of other AML subtypes and normal hematopoietic progenitor cells do not express CD163. We provide evidence that the functional characteristics of CD163 are preserved on malignant cells by showing the capability of types M4/M5 blast cells to internalize Hb–Hp by a CD163‐mediated mechanism. Together, our results identify CD163 as a potential target for therapeutic intervention. It is important that CD163 does not appear to be released from leukemic blasts under noninflammatory conditions, thus reducing the probability of off‐target side‐effects as a result of competitive binding of potential therapeutic ligands to nonmembrane‐bound CD163.