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Interferon‐γ: an overview of signals, mechanisms and functions
Author(s) -
Schroder Kate,
Hertzog Paul J.,
Ravasi Timothy,
Hume David A.
Publication year - 2004
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0603252
Subject(s) - biology , signal transduction , microbiology and biotechnology , tumor necrosis factor alpha , effector , interferon gamma , receptor , macrophage , cytokine , immunology , function (biology) , lipopolysaccharide , interferon , genetics , in vitro
Interferon‐γ (IFN‐γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN‐γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN‐γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN‐γ are described, including up‐regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen‐associated molecular patterns, such as tumor necrosis factor‐α, interleukin‐4, type I IFNs, and lipopolysaccharide are discussed.