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Chronic myeloid leukemic cells trigger poly(ADP‐ribose) polymerase‐dependent inactivation and cell death in lymphocytes
Author(s) -
Aurelius Johan,
Martner Anna,
Riise Rebecca E.,
Romero Ana I.,
Palmqvist Lars,
Brune Mats,
Hellstrand Kristoffer,
Thorén Fredrik B.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0512257
Subject(s) - biology , k562 cells , cytotoxic t cell , cancer research , programmed cell death , poly adp ribose polymerase , interleukin 21 , immunology , viability assay , microbiology and biotechnology , t cell , leukemia , cell , apoptosis , immune system , enzyme , polymerase , in vitro , biochemistry
CML cells induce PARP‐1 dependent parthanatos in NK cells, and inhibition of PARP‐1 maintains lymphocyte viability and function.