Premium
Granzyme B‐ and Fas ligand‐mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4 + T cells
Author(s) -
Medina Miguel A.,
Couturier Jacob,
Feske Marsha L.,
Mahne Ashley E.,
Turner Mary,
Yu Xiaoyong,
Kozinetz Claudia A.,
Orozco Aaron F.,
Hutchison Alexander T.,
Savidge Tor C.,
Rodgers John R.,
Lewis Dorothy E.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0511264
Subject(s) - cytotoxic t cell , cd28 , biology , granzyme b , granzyme , interleukin 21 , fas ligand , t cell , il 2 receptor , microbiology and biotechnology , immunology , immune system , cd8 , perforin , apoptosis , in vitro , programmed cell death , biochemistry
Mitogenic CD28 (or Superagonistic CD28) antibodies activate CTL functions by human CD4+ T cells—functions previously unknown to be induced by these stimulatory antibodies.