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The glucocorticoid dexamethasone programs human dendritic cells for enhanced phagocytosis of apoptotic neutrophils and inflammatory response
Author(s) -
Hodrea Judit,
Majai Gyöngyike,
Doró Zoltán,
Zahuczky Gábor,
Pap Attila,
Rajnavölgyi Éva,
Fésüs László
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0511243
Subject(s) - proinflammatory cytokine , cd14 , mertk , biology , phagocytosis , microbiology and biotechnology , immunology , apoptosis , dendritic cell , priming (agriculture) , inflammation , immune system , signal transduction , biochemistry , botany , germination , receptor tyrosine kinase
Differentiation of DC with dexamethasone leads to elevated apoptotic neutrophil phagocytosis, through the up‐regulation of apoptophagocytic genes, and to proinflammatory T cell response.