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The monomer‐dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue‐specific neutrophil recruitment
Author(s) -
Gangavarapu Pavani,
Rajagopalan Lavanya,
Kolli Deepthi,
GuerreroPlata Antonieta,
Garofalo Roberto P.,
Rajarathnam Krishna
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0511239
Subject(s) - chemokine , dimer , microbiology and biotechnology , chemotaxis , biology , in vivo , glycosaminoglycan , interleukin 8 , biophysics , monomer , chemokine receptor , chemistry , receptor , biochemistry , immunology , inflammation , organic chemistry , polymer
Chemokine production, the chemokine monomer‐dimer equilibrium, and differences in GAG‐interactions collectively influence in vivo tissue‐specific patterns of chemokine gradient formation and neutrophil recruitment.