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TLR2‐dependent modulation of dendritic cells by LT‐IIa‐B 5 , a novel mucosal adjuvant derived from a type II heat‐labile enterotoxin
Author(s) -
Lee Chang Hoon,
MassoWelch Patricia,
Hajishengallis George,
Connell Terry D.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0511236
Subject(s) - biology , cd80 , adjuvant , cd86 , tlr2 , immune system , immunology , enterotoxin , c c chemokine receptor type 7 , dendritic cell , in vivo , cd40 , t cell , in vitro , chemokine , innate immune system , gene , biochemistry , cytotoxic t cell , escherichia coli , chemokine receptor , microbiology and biotechnology
The immunomodulatory activities of LT‐IIa‐B5 depend upon the adjuvantsˈs capacity to activate and promote migration of DC in mucosal tissues in a strictly TLR2‐dependent manner.