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Calcium/calmodulin‐dependent protein kinase (CaMK) Iα mediates the macrophage inflammatory response to sepsis
Author(s) -
Zhang Xianghong,
Guo Lanping,
Collage Richard D.,
Stripay Jennifer L.,
Tsung Allan,
Lee Janet S.,
Rosengart Matthew R.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0510286
Subject(s) - biology , hmgb1 , inflammation , camk , microbiology and biotechnology , sepsis , signal transduction , rna interference , in vivo , kinase , autophagy , protein kinase a , immunology , apoptosis , biochemistry , gene , rna , autophosphorylation
CaMKIα regulates systemic inflammation and organ dysfunction during sepsis by regulating secretory lysosomal HMGB1 release and IL‐10 production in macrophages exposed to LPS.