z-logo
Premium
Calcium/calmodulin‐dependent protein kinase (CaMK) Iα mediates the macrophage inflammatory response to sepsis
Author(s) -
Zhang Xianghong,
Guo Lanping,
Collage Richard D.,
Stripay Jennifer L.,
Tsung Allan,
Lee Janet S.,
Rosengart Matthew R.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0510286
Subject(s) - biology , hmgb1 , inflammation , camk , microbiology and biotechnology , sepsis , signal transduction , rna interference , in vivo , kinase , autophagy , protein kinase a , immunology , apoptosis , biochemistry , gene , rna , autophosphorylation
CaMKIα regulates systemic inflammation and organ dysfunction during sepsis by regulating secretory lysosomal HMGB1 release and IL‐10 production in macrophages exposed to LPS.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here