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Loss of TRPC1‐mediated Ca 2+ influx contributes to impaired degranulation in Fyn‐deficient mouse bone marrow‐derived mast cells
Author(s) -
Suzuki Ryo,
Liu Xibao,
Olivera Ana,
Aguiniga Lizath,
Yamashita Yumi,
Blank Ulrich,
Ambudkar Indu,
Rivera Juan
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0510253
Subject(s) - orai1 , fyn , degranulation , microbiology and biotechnology , biology , stim1 , calcium in biology , thapsigargin , voltage dependent calcium channel , calcium , intracellular , medicine , phosphorylation , biochemistry , proto oncogene tyrosine protein kinase src , receptor , endoplasmic reticulum
Fyn‐dependent expression of the cationic transient receptor potential channel 1 contributes to mast cell Ca 2+ influx, cortical F‐actin depolymerization, and degranulation.