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Robust erythrophagocytosis leads to macrophage apoptosis via a hemin‐mediated redox imbalance: role in hemolytic disorders
Author(s) -
Cambos Mathieu,
Scorza Tatiana
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0510249
Subject(s) - apoptosis , phagocytosis , biology , hemin , microbiology and biotechnology , in vitro , reactive oxygen species , immunology , heme , biochemistry , enzyme
Robust erythrophagocytosis and concomitant ingestion of hemin lead to the generation of ROS responsible for J774A.1 MP apoptosis.
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