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Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll‐like receptor 4 agonist LPS
Author(s) -
Halili Maria A.,
Andrews Melanie R.,
Labzin Larisa I.,
Schroder Kate,
Matthias Gabriele,
Cao Chun,
Lovelace Erica,
Reid Robert C.,
Le Giang T.,
Hume David A.,
Irvine Katharine M.,
Matthias Patrick,
Fairlie David P.,
Sweet Matthew J.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509363
Subject(s) - proinflammatory cytokine , hdac6 , tlr4 , inflammation , biology , macrophage , lipopolysaccharide , immunology , histone deacetylase , cancer research , microbiology and biotechnology , pharmacology , in vitro , histone , biochemistry , gene
Selective inhibitor studies in macrophages implicate class II HDAC enzymes in TLR‐mediated inflammatory pathways and class I HDACs as negative regulators.