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Higher activation of TLR9 in plasmacytoid dendritic cells by microbial DNA compared with self‐DNA based on CpG‐specific recognition of phosphodiester DNA
Author(s) -
Coch Christoph,
Busch Nicolas,
Wimmenauer Vera,
Hartmann Evelyn,
Janke Markus,
AbdelMottaleb Mona Mohamed Ahmed,
Lamprecht Alf,
Ludwig Janos,
Barchet Winfried,
Schlee Martin,
Hartmann Gunther
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509314
Subject(s) - phosphodiester bond , dna , biology , cpg site , dna methylation , microbiology and biotechnology , biochemistry , recombinant dna , gene , gene expression , rna
Mammalian genomic DNA complexed to the natural antimicrobial cationic peptide LL37 induces type I interferon but less than bacterial DNA or CG‐dinucleotide containing oligodeoxynucleotides.