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The role of interferon‐γ in the pathogenesis of acute intra‐abdominal sepsis
Author(s) -
Romero Christopher R.,
Herzig Daniela S.,
Etogo Anthony,
Nunez Jesus,
Mahmoudizad Rod,
Fang Geping,
Murphey E. D.,
ToliverKinsky Tracy,
Sherwood Edward R.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509307
Subject(s) - septic shock , immunology , splenocyte , sepsis , proinflammatory cytokine , biology , spleen , interferon , myeloid , pathogenesis , systemic inflammation , inflammation , cytokine , interferon gamma
IFNγ produced by intraperitoneal myeloid and NK cells during cecal ligation/puncture‐induced septic shock facilitates myeloid cell activation yet blockade of IFNγ does not improve survival.

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