Premium
Induction of HIF‐1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
Author(s) -
Larbi Anis,
Zelba Henning,
Goldeck David,
Pawelec Graham
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509304
Subject(s) - biology , cd28 , t cell , apoptosis , glycolysis , microbiology and biotechnology , cd8 , cell growth , cell , programmed cell death , immune system , biochemistry , immunology , metabolism
T cell differentiation and functions are altered at low oxygen, possibly via HIF‐1α and glycolysis up‐regulation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom