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Induction of HIF‐1α and the glycolytic pathway alters apoptotic and differentiation profiles of activated human T cells
Author(s) -
Larbi Anis,
Zelba Henning,
Goldeck David,
Pawelec Graham
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509304
Subject(s) - biology , cd28 , t cell , apoptosis , glycolysis , microbiology and biotechnology , cd8 , cell growth , cell , programmed cell death , immune system , biochemistry , immunology , metabolism
T cell differentiation and functions are altered at low oxygen, possibly via HIF‐1α and glycolysis up‐regulation.