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Regulation of macrophage motility by Irgm1
Author(s) -
Henry Stanley C.,
Traver Maria,
Daniell Xiaojou,
Indaram Maanasa,
Oliver Tim,
Taylor Gregory A.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0509299
Subject(s) - microbiology and biotechnology , biology , motility , cytoskeleton , lamellipodium , intracellular , actin cytoskeleton , actin , membrane ruffling , macrophage , biochemistry , cell , in vitro
Irgm1 controls macrophage motility by regulating the positioning of specific GKS IRG proteins to the plasma membrane, leading to altered Rac activity and actin remodelling.