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Cytokine‐induced killer T cells kill immature dendritic cells by TCR‐independent and perforin‐dependent mechanisms
Author(s) -
Joshi Pramod S.,
Liu JinQing,
Wang Yin,
Chang Xing,
Richards John,
Assarsson Erika,
Shi FuDong,
Ljunggren HansGustaf,
Bai XueFeng
Publication year - 2006
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0506305
Subject(s) - biology , perforin , cytokine induced killer cell , cytotoxic t cell , natural killer t cell , interleukin 12 , interleukin 21 , microbiology and biotechnology , immunology , t cell receptor , dendritic cell , ex vivo , t cell , cytokine , antigen presenting cell , immune system , in vitro , cd3 , cd8 , biochemistry
Cytokine‐induced killer (CIK) cells are ex vivo, expanded T cells with proven anticancer activity in vitro and in vivo. However, their functional properties with the exception of their cancer cell‐killing activity are largely unclear. Here, we show that CIK T cells recognize dendritic cells (DC), and although mature DC (mDC) induce CIK T cells to produce IFN‐γ, immature DC (iDC) are killed selectively by them. Moreover, CIK T cell activation by mDC and their destruction of iDC are independent of the TCR. The cytotoxicity of CIK T cells to iDC is perforin‐dependent. Our data have revealed an important regulatory role of CIK cells.