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Distribution and leukocyte contacts of γδ T cells in the lung
Author(s) -
Wands J. M.,
Roark Christina L.,
Aydintug M. Kemal,
Jin Niyun,
Hahn YounSoo,
Cook Laura,
Yin Xiang,
Dal Porto Joseph,
Lahn Michael,
Hyde Dallas M.,
Gelfand Erwin W.,
Mason Robert J.,
O’Brien Rebecca L.,
Born Willi K.
Publication year - 2005
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0505244
Subject(s) - biology , lung , major histocompatibility complex , immunology , microbiology and biotechnology , immune system , medicine
Pulmonary γδ T cells protect the lung and its functions, but little is known about their distribution in this organ and their relationship to other pulmonary cells. We now show that γδ and αβ T cells are distributed differently in the normal mouse lung. The γδ T cells have a bias for nonalveolar locations, with the exception of the airway mucosa. Subsets of γδ T cells exhibit further variation in their tissue localization. γδ and αβ T cells frequently contact other leukocytes, but they favor different cell‐types. The γδ T cells show an intrinsic preference for F4/80 + and major histocompatibility complex class II + leukocytes. Leukocytes expressing these markers include macrophages and dendritic cells, known to function as sentinels of airways and lung tissues. The continuous interaction of γδ T cells with these sentinels likely is related to their protective role.