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N6‐isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation
Author(s) -
Ciaglia Elena,
Pisanti Simona,
Picardi Paola,
Laezza Chiara,
Malfitano Anna Maria,
DˈAlessandro Alba,
Gazzerro Patrizia,
Vitale Mario,
Carbone Ennio,
Bifulco Maurizio
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0413190
Subject(s) - biology , microbiology and biotechnology , mevalonate pathway , cytotoxic t cell , signal transduction , effector , biochemistry , in vitro , enzyme , reductase
Molecular mechanisms by which the isoprenoid derivative iPA synergizes with IL‐2, for the expansion and cytotoxicity of human primary NK cells.