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Ca 2+ activation of cytosolic calpain induces the transition from apoptosis to necrosis in neutrophils with externalized phosphatidylserine
Author(s) -
Francis R. J.,
Kotecha S.,
Hallett M. B.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0412212
Subject(s) - calpain , phosphatidylserine , necrosis , apoptosis , biology , cytosol , microbiology and biotechnology , ionomycin , in vitro , immunology , biochemistry , intracellular , membrane , phospholipid , enzyme , genetics
Imaging individual aged neutrophils reveals elevated cytosolic Ca 2+ in cells with externalized PS, which are vulnerable to necrosis by subsequent elevations of Ca 2+ .
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