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Tumor necrosis factor α‐converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163
Author(s) -
Etzerodt Anders,
Maniecki Maciej Bogdan,
Møller Kirsten,
Møller Holger Jon,
Moestrup Søren Kragh
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0410235
Subject(s) - ectodomain , cd163 , scavenger receptor , biology , tumor necrosis factor alpha , metalloproteinase , haptoglobin , receptor , inflammation , macrophage , transmembrane protein , microbiology and biotechnology , matrix metalloproteinase , cancer research , immunology , biochemistry , cholesterol , in vitro , lipoprotein
TACE/ADAM17‐mediated shedding of CD163 likely explains the empirical relationship between the sCD163 plasma level and infectious/inflammatory diseases relating to macrophage activity.