Tumor necrosis factor α‐converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163 | Zendy

Etzerodt Anders | Zendy; Maniecki Maciej Bogdan | Zendy; Møller Kirsten | Zendy; Møller Holger Jon | Zendy; Moestrup Søren Kragh | Zendy

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Tumor necrosis factor α‐converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163

Author(s) -

Etzerodt Anders,

Maniecki Maciej Bogdan,

Møller Kirsten,

Møller Holger Jon,

Moestrup Søren Kragh

Publication year - 2010

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0410235

Subject(s) - ectodomain , cd163 , scavenger receptor , biology , tumor necrosis factor alpha , metalloproteinase , haptoglobin , receptor , inflammation , macrophage , transmembrane protein , microbiology and biotechnology , matrix metalloproteinase , cancer research , immunology , biochemistry , cholesterol , in vitro , lipoprotein

TACE/ADAM17‐mediated shedding of CD163 likely explains the empirical relationship between the sCD163 plasma level and infectious/inflammatory diseases relating to macrophage activity.

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