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Cytohesin‐1 regulates fMLF‐mediated activation and functions of the β 2 integrin Mac‐1 in human neutrophils
Author(s) -
El Azreq MohammedAmine,
Garceau Valérie,
Bourgoin Sylvain G.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0410222
Subject(s) - biology , integrin , microbiology and biotechnology , neutrophile , immunology , integrin alpha m , downregulation and upregulation , nadph oxidase , receptor , reactive oxygen species , inflammation , biochemistry , gene , flow cytometry
Cytohesin‐1 inhibition or silencing enhances fMLF‐induced Mac‐1 activation, Mac‐1‐dependent adhesion to fibrinogen and phagocytosis whereas cytohesin‐1 over‐expression restrains Mac‐1 activity in polymorphonuclear neutrophils.