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Pivotal Advance: Kaposi's sarcoma‐associated herpesvirus (KSHV)‐encoded microRNA specifically induce IL‐6 and IL‐10 secretion by macrophages and monocytes
Author(s) -
Qin Zhiqiang,
Kearney Patricia,
Plaisance Karlie,
Parsons Chris H.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0409251
Subject(s) - biology , kaposi's sarcoma associated herpesvirus , cytokine , immune system , secretion , tumor microenvironment , cancer research , microrna , innate immune system , transcription factor , immunology , microbiology and biotechnology , virus , gene , biochemistry , viral disease , herpesviridae
MicroRNA encoded by KSHV, a common tumor virus, induces macrophage secretion of tumor‐promoting cytokines by down‐regulating the transcription factor C/EBPβ p20 isoform (LIP).