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The T cell receptor‐mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems
Author(s) -
Collins Michaela,
Tremblay Mikaela,
Chapman Nicole,
Curtiss Miranda,
Rothman Paul B.,
Houtman Jon C. D.
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0409227
Subject(s) - microbiology and biotechnology , phosphorylation , biology , tyrosine protein kinase csk , t cell receptor , fyn , tyrosine phosphorylation , proto oncogene tyrosine protein kinase src , signal transduction , phosphorylation cascade , sh2 domain , protein phosphorylation , t cell , protein kinase a , immunology , immune system
The T cell receptor has a distinct mechanism for the site‐specific phosphorylation of Pyk2 that requires Src family kinases, but not other pathways.