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Release of IL‐12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy
Author(s) -
Krummen Mathias,
Balkow Sandra,
Shen Limei,
Heinz Stefanie,
Loquai Carmen,
Probst HansChristian,
Grabbe Stephan
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0408228
Subject(s) - trif , autocrine signalling , microbiology and biotechnology , tlr4 , biology , toll like receptor , signal transduction , in vivo , in vitro , receptor , innate immune system , biochemistry
Synergistic activation of dendritic cells by combinations of TLR ligands requires both MyD88‐ and TRIF‐dependent signaling.