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Differential expression of β 2 ‐integrins and cytokine production between γδ and αβ T cells in experimental autoimmune encephalomyelitis
Author(s) -
Smith Sherry S.,
Barnum Scott R.
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0407263
Subject(s) - experimental autoimmune encephalomyelitis , biology , cytokine , immunology , integrin , spleen , encephalomyelitis , microbiology and biotechnology , inflammation , cell , multiple sclerosis , genetics
The expression of β 2 ‐integrins on γδ T cells in naïve mice or those with experimental autoimmune encephalomyelitis (EAE) remains poorly characterized. We compared β 2 ‐integrin expression and cytokine production between γδ and αβ T cells over the acute course of EAE. We observed that unlike in αβ T cells, β 2 ‐integrin expression on γδ T cells increased significantly from baseline, peaked at Day 10, and remained unchanged in the draining lymph nodes or declined in the spleen and CNS by Day 15. In addition, IFN‐γ‐ and TNF‐α‐producing γδ T cells infiltrated the CNS rapidly and produced significantly more of these cytokines than αβ T cells throughout the course of EAE. These results suggest unique roles for β 2 ‐integrins in the trafficking of γδ versus αβ T cells during EAE and that γδ T cells infiltrate the CNS rapidly, producing cytokines, which modulate acute disease.