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Loss of function in virus‐specific lung effector T cells is independent of infection
Author(s) -
Arimilli Subhashini,
Palmer Ellen M.,
AlexanderMiller Martha A.
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0407215
Subject(s) - biology , effector , function (biology) , virus , virology , immunology , lung function , lung , microbiology and biotechnology , medicine
Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus‐specific CD8 + effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed to be the result of infection‐induced changes in the lung. Although virus‐specific effects may contribute to regulation of T cells in the lung, the findings from this study provide evidence that the basal lung environment is sufficient to promote loss of function in effector cells. Loss of function occurs within 48 h of entry into the lung and is most evident in cells residing in the lung parenchyma. These findings suggest an additional paradigm for the immunoregulation of effector cells that enter the lung as a result of virus infection.