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p66Shc regulates vesicle‐mediated secretion in mast cells by affecting F‐actin dynamics
Author(s) -
Masi Giulia,
Mercati David,
Vannuccini Elisa,
Paccagnini Eugenio,
Riparbelli Maria Giovanna,
Lupetti Pietro,
Pelicci Pier Giuseppe,
Baldari Cosima T.,
Ulivieri Cristina
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0313178
Subject(s) - biology , secretion , microbiology and biotechnology , secretory vesicle , vesicle , actin , mast (botany) , dynamics (music) , mast cell , exocytosis , immunology , biochemistry , membrane , physics , acoustics
p66Shc is recruited as a complex with SHIP‐1 to the F‐actin skeleton, and negatively regulates mast cell secretion and membrane ruffling by impairing F‐actin dynamics.