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AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling
Author(s) -
Carroll Kelly Casey,
Viollet Benoit,
Suttles Jill
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0313157
Subject(s) - proinflammatory cytokine , ampk , cd40 , antigen presentation , biology , microbiology and biotechnology , protein kinase a , protein kinase b , t cell , signal transduction , immunology , inflammation , kinase , immune system , cytotoxic t cell , biochemistry , in vitro
AMPK attenuates CD40‐mediated inflammatory activity in myeloid APC; its activity in both APC and T cells contributes to T cell functional polarization.