Premium
Biliary obstruction results in PD‐1‐dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
Author(s) -
Licata Lauren A.,
Nguyen Cang T.,
Burga Rachel A.,
Falanga Vincent,
Espat N. Joseph,
Ayala Alfred,
Thorn Mitchell,
Junghans Richard P.,
Katz Steven C.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0313137
Subject(s) - inflammation , cholestasis , immunology , liver injury , t cell , cytokine , immunosuppression , biology , immune system , medicine , endocrinology
Intrahepatic inflammation and liver T cell dysfunction due to obstructive jaundice are both ameliorated through abrogation of PD‐1 expression.