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Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL‐7‐mediated activities in human CD8 + T cells
Author(s) -
Crawley Angela M.,
Vranjkovic Agatha,
Faller Elliott,
McGuinty Michaeline,
Busca Aurelia,
Burke Stephanie C.,
Cousineau Sophie,
Kumar Ashok,
MacPherson Paul A.,
Angel Jonathan B.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0313122
Subject(s) - biology , stat5 , signal transduction , jak stat signaling pathway , microbiology and biotechnology , t cell , pi3k/akt/mtor pathway , perforin , cytokine , stat , cytotoxic t cell , cd8 , interleukin 15 , immunology , interleukin , immune system , stat3 , tyrosine kinase , biochemistry , in vitro
Inhibition of Jak activation in CD8 T cells reduced IL‐7‐induced Bcl‐2, and perforin production, while inhibition of either Jak/STAT or PI3K pathways reduced glucose uptake and proliferation.