Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL‐7‐mediated activities in human CD8 +  T cells | Zendy

Crawley Angela M. | Zendy; Vranjkovic Agatha | Zendy; Faller Elliott | Zendy; McGuinty Michaeline | Zendy; Busca Aurelia | Zendy; Burke Stephanie C. | Zendy; Cousineau Sophie | Zendy; Kumar Ashok | Zendy; MacPherson Paul A. | Zendy; Angel Jonathan B. | Zendy

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Jak/STAT and PI3K signaling pathways have both common and distinct roles in IL‐7‐mediated activities in human CD8 + T cells

Author(s) -

Crawley Angela M.,

Vranjkovic Agatha,

Faller Elliott,

McGuinty Michaeline,

Busca Aurelia,

Burke Stephanie C.,

Cousineau Sophie,

Kumar Ashok,

MacPherson Paul A.,

Angel Jonathan B.

Publication year - 2014

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.0313122

Subject(s) - biology , stat5 , signal transduction , jak stat signaling pathway , microbiology and biotechnology , t cell , pi3k/akt/mtor pathway , perforin , cytokine , stat , cytotoxic t cell , cd8 , interleukin 15 , immunology , interleukin , immune system , stat3 , tyrosine kinase , biochemistry , in vitro

Inhibition of Jak activation in CD8 T cells reduced IL‐7‐induced Bcl‐2, and perforin production, while inhibition of either Jak/STAT or PI3K pathways reduced glucose uptake and proliferation.

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