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B7‐1/B7‐2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3 + regulatory T cells
Author(s) -
Ertelt James M.,
Buyukbasaran Esra Z.,
Jiang Tony T.,
Rowe Jared H.,
Xin Lijun,
Way Sing Sing
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0313118
Subject(s) - cytotoxic t cell , cd80 , cd86 , biology , foxp3 , microbiology and biotechnology , immunology , cd28 , cd8 , t cell , ctla 4 , il 2 receptor , cytokine , immune system , cd40 , biochemistry , in vitro
The activation of protective CD8 T cells requires B7‐1/B7‐2 costimulation, even when suppression by Tregs, and in particular, Treg intrinsic CTLA‐4, is circumvented.