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Reduced numbers of dendritic cells with a tolerogenic phenotype in the prediabetic pancreas of NOD mice
Author(s) -
WelzenCoppens Jojanneke M. C.,
HeldenMeeuwsen Cornelia G.,
Leenen Pieter J. M.,
Drexhage Hemmo A.,
Versnel Marjan A.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312168
Subject(s) - nod mice , nod , biology , insulitis , immunology , langerin , pancreas , cd8 , population , pancreatic islets , immune tolerance , immune system , dendritic cell , endocrinology , autoimmunity , diabetes mellitus , islet , medicine , environmental health
Local abnormalities in CD8κ + DCs in the pre‐diabetic NOD pancreas suggest that these DCs contribute to loss of tolerance, hallmarking the development of autoimmune diabetes.