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BET bromodomain inhibition as a novel strategy for reactivation of HIV‐1
Author(s) -
Banerjee Camellia,
Archin Nancie,
Michaels Daniel,
Belkina Anna C.,
Denis Gerald V.,
Bradner James,
Sebastiani Paola,
Margolis David M.,
Montano Monty
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312165
Subject(s) - bromodomain , biology , brd4 , bet inhibitor , histone , chromatin , gene , epigenetics , t cell , cancer research , microbiology and biotechnology , immunology , genetics , immune system
BET bromodomain antagonist JQ1 reactivates HIV‐1, while suppressing T cell activation genes, and upregulating histone modification genes that favor increased Tat activity.