z-logo
Premium
BET bromodomain inhibition as a novel strategy for reactivation of HIV‐1
Author(s) -
Banerjee Camellia,
Archin Nancie,
Michaels Daniel,
Belkina Anna C.,
Denis Gerald V.,
Bradner James,
Sebastiani Paola,
Margolis David M.,
Montano Monty
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312165
Subject(s) - bromodomain , biology , brd4 , bet inhibitor , histone , chromatin , gene , epigenetics , t cell , cancer research , microbiology and biotechnology , immunology , genetics , immune system
BET bromodomain antagonist JQ1 reactivates HIV‐1, while suppressing T cell activation genes, and upregulating histone modification genes that favor increased Tat activity.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here