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IRF3 contributes to sepsis pathogenesis in the mouse cecal ligation and puncture model
Author(s) -
Walker Wendy E.,
Bozzi Aaron T.,
Goldstein Daniel R.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312138
Subject(s) - irf3 , sepsis , biology , immunology , innate immune system , tlr9 , ligation , immune system , gene , microbiology and biotechnology , gene expression , biochemistry , dna methylation
IRF3 is identified as a key mediator of inflammatory markers, bacteremia, and disease pathogenesis, in the cecal ligation and puncture model of sepsis.