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ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation
Author(s) -
Manohar Monali,
Hirsh Mark I.,
Chen Yu,
Woehrle Tobias,
Karande Anjali A.,
Junger Wolfgang G.
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312121
Subject(s) - purinergic receptor , autocrine signalling , microbiology and biotechnology , purinergic signalling , biology , cd28 , paracrine signalling , receptor , signal transduction , jurkat cells , extracellular , t cell , immune system , biochemistry , immunology , adenosine receptor , agonist
Circulating human γδ T cells release ATP upon in vitro stimulation, which signals through P2X4 receptors and governs these cellsˈ function.