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ADAM17 activation in circulating neutrophils following bacterial challenge impairs their recruitment
Author(s) -
Long Chunmei,
Hosseinkhani M. Reza,
Wang Yue,
Sriramarao P.,
Walcheck Bruce
Publication year - 2012
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0312112
Subject(s) - knockout mouse , biology , conditional gene knockout , peritoneal cavity , inflammation , neutrophil extracellular traps , immunology , microbiology and biotechnology , gene knockout , phenotype , gene , genetics , anatomy
ADAM17 functions as a molecular rheostat to control neutrophil influx at sites of infection by regulating the surface density of L‐selectin.