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Apple polyphenols require T cells to ameliorate dextran sulfate sodium‐induced colitis and dampen proinflammatory cytokine expression
Author(s) -
Skyberg Jerod A.,
Robison Amy,
Golden Sarah,
Rollins MaryClare F.,
Callis Gayle,
Huarte Eduardo,
Kochetkova Irina,
Jutila Mark A.,
Pascual David W.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0311168
Subject(s) - proinflammatory cytokine , colitis , cxcl10 , immunology , cytokine , cxcl9 , chemokine , inflammatory bowel disease , cxcr3 , inflammation , biology , cd8 , tumor necrosis factor alpha , medicine , immune system , chemokine receptor , disease
Administration of apple polyphenols protects against experimental colitis by diminishing proinflammatory cytokine expression and TCRαβ cell activation in the colon.