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Regulation of corneal inflammation by neutrophil‐dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient
Author(s) -
Carlson Eric C.,
Sun Yan,
Auletta Jeffery,
Kao Winston W.Y.,
Liu ChiaYang,
Perez Victor L.,
Pearlman Eric
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0310134
Subject(s) - lumican , cornea , keratan sulfate , cxcl1 , chemokine , inflammation , proteoglycan , microbiology and biotechnology , extracellular matrix , corneal inflammation , biology , immunology , chemistry , neuroscience , decorin
Keratan sulfate proteoglycans are degraded by PMNs and detected with CXC chemokines in the anterior chamber to initiate the resolution process of LPS‐induced inflammation.