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Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions
Author(s) -
Lee Jack Y.,
Buzney Catherine D.,
Poznansky Mark C.,
Sackstein Robert
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0309214
Subject(s) - intravasation , chemokine , microbiology and biotechnology , chemotaxis , extravasation , biology , ccl5 , internalization , compartment (ship) , chemokine receptor , integrin , immunology , cell , receptor , inflammation , t cell , genetics , immune system , cancer , il 2 receptor , cancer cell , geology , biochemistry , oceanography
Findings support a novel paradigm by which temporospatial modulations in subendothelial chemokine display drive cell migration from interstitial compartments into the bloodstream.