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Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll‐like receptor 2 with partial involvement of MyD88
Author(s) -
Yang Jihyun,
Ryu Young Hee,
Yun CheolHeui,
Han Seung Hyun
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0309206
Subject(s) - osteoclast , lipoteichoic acid , rankl , tlr2 , bone resorption , macrophage colony stimulating factor , microbiology and biotechnology , mapk/erk pathway , monocyte , biology , receptor , signal transduction , macrophage , immunology , biochemistry , staphylococcus aureus , endocrinology , tlr4 , activator (genetics) , bacteria , in vitro , genetics
Staphylococcal LTA inhibits osteoclast differentiation primarily through TLR2; and in part through MyD88 signaling, which in turn inhibits activation of ERK, JNK, and AP‐1.