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Enhanced production of IL‐17A during zymosan‐induced peritonitis in obese mice
Author(s) -
Pini Maria,
Fantuzzi Giamila
Publication year - 2010
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0309188
Subject(s) - chemokine , inflammation , medicine , endocrinology , adipose tissue , proinflammatory cytokine , ccl2 , zymosan , leptin , interleukin 17 , immunology , cytokine , tumor necrosis factor alpha , immune system , diet induced obese , biology , obesity , insulin resistance , biochemistry , in vitro
Neutrophils from obese mice produce high levels of the pro‐inflammatory cytokine IL‐17A following zymosan administration; this cytokine contributes to exacerbation and delayed resolution of peritoneal inflammation in obesity.