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Cholesterol‐dependent cytolysins induce rapid release of mature IL‐1β from murine macrophages in a NLRP3 inflammasome and cathepsin B‐dependent manner
Author(s) -
Chu Jessica,
Thomas L. Michael,
Watkins Simon C.,
Franchi Luigi,
Núñez Gabriel,
Salter Russell D.
Publication year - 2009
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0309164
Subject(s) - inflammasome , secretion , biology , cathepsin b , caspase 1 , microbiology and biotechnology , cathepsin , biochemistry , receptor , enzyme
This study explores the mechanism by which a bacterial toxin induces the secretion of a proinflammatory cytokine from innate immune cells.