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A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
Author(s) -
Kagimoto Yoshiko,
Yamada Hisakata,
Ishikawa Takahiro,
Maeda Naoyoshi,
Goshima Fumi,
Nishiyama Yukihiro,
Furue Masutaka,
Yoshikai Yasunobu
Publication year - 2008
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0307137
Subject(s) - biology , immunology , wound healing , inflammation , intraepithelial lymphocyte , immune system
IL‐15 plays a critical role in the development and maturation of γδ intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL‐15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV‐2. The IEL in the skin and reproductive organs of IL‐15 Tg mice produced an aberrantly higher level of TGF‐β1 upon TCR triggering than in control mice. In vivo neutralization of TGF‐β ameliorated the susceptibility of IL‐15 Tg mice to genital HSV‐2 infection. Taken together, overexpression of IL‐15 may stimulate IEL to produce TGF‐β1, promoting wound healing but impeding protection against genital HSV‐2 infection.