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Contrasting effects of FLIP L overexpression in human T cells on activation‐induced cell death and cytokine production
Author(s) -
Charo Jehad,
Robbins Paul F.
Publication year - 2007
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0306218
Subject(s) - biology , proinflammatory cytokine , t cell , microbiology and biotechnology , antigen , cytokine , stimulation , immunology , immune system , inflammation , neuroscience
There have been disparate findings about the role of FLIP in the survival of mouse T cells and human tumor cell lines. The role of cellular FLIP in human T cell activation and function needs to be clarified further. To study this role, we have overexpressed long transcript FLIP (FLIP L ) in primary T cells, including self‐antigen‐reactive, melanoma‐specific T cells. We found that FLIP L overexpression protects human T cells from activation‐induced cell death and enhances their prolifertive capacity but suppresses the ability of these cells to produce the proinflammatory cytokines IL‐2 and IFN‐γ in response to CD3 or antigen‐specific stimulation. The multiple effects of FLIP L indicate that this protein may influence T cell responses to antigenic stimulation.