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RIP2 activity in inflammatory disease and implications for novel therapeutics
Author(s) -
Jun Janice C.,
Cominelli Fabio,
Abbott Derek W.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0213109
Subject(s) - nod2 , disease , loss function , gain of function , inflammatory bowel disease , immunology , biology , inflammation , chronic granulomatous disease , function (biology) , medicine , mutation , crohn's disease , genetics , pathology , phenotype , gene
Review on the role that the NOD2:RIP2 complex plays in inflammatory disease, with an emphasis on its inhibition as a future drug target.