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Accumulation of M1‐like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization
Author(s) -
Cucak Helena,
Grunnet Lars Groth,
Rosendahl Alexander
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0213075
Subject(s) - proinflammatory cytokine , biology , macrophage polarization , islet , cd80 , cd68 , cd86 , macrophage , inflammation , cd14 , immunology , cytokine , medicine , endocrinology , immune system , diabetes mellitus , cd40 , cytotoxic t cell , t cell , immunohistochemistry , in vitro , biochemistry
Two distinct subsets of pro‐inflammatory M1‐like macrophages invade type 2 diabetic islets at a time‐point when β‐cells undergo apoptosis, and blood glucose control is lost.