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IL‐8‐mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation
Author(s) -
Kyriakakis Emmanouil,
Cavallari Marco,
Pfaff Dennis,
Fabbro Doriano,
Mestan Juergen,
Philippova Maria,
De Libero Gennaro,
Erne Paul,
Resink Therese J.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0211097
Subject(s) - microbiology and biotechnology , angiogenesis , cancer research , neovascularization , biology , mapk/erk pathway , proto oncogene tyrosine protein kinase src , signal transduction , transactivation , chemokine , cell migration , immunology , cell , immune system , biochemistry , gene , transcription factor , genetics
A selective cascade of proangiogenic events occurs following antigen‐stimulation of iNKT cells and attribute EGFR a novel function in inflammation‐driven neovascularization within atherosclerotic plaques.