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Immunomodulatory and immunotoxic effects of bilirubin: molecular mechanisms
Author(s) -
Khan Nazir M.,
Poduval T. B.
Publication year - 2011
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.0211070
Subject(s) - splenocyte , apoptosis , biology , immune system , immunology , spleen , cytokine , microbiology and biotechnology , biochemistry
Unconjugated bilirubin induces immunotoxicity both in vivo and in vitro via activation of apoptosis mediated by up‐regulation of p38MAPK and necrosis.